Tuesday, August 07, 2007

Some Side Effects of Cymbalta

The following information is taken from the WikiPedia article on Duloxetine, the generic name for Cymbalta.

Since duloxetine is a newer drug (FDA approved in 2004), few peer-reviewed articles have been published on its adverse effects, and effects of long-term use are still unknown. More than 40 different types of adverse effects have been reported, including completed suicide attempts and severe hepatic disorders.
  • Journalists Jeanne Lenzer and Nicholas Pyke, writing for The Independent newspaper, uncovered 41 deaths and 13 suicides for patients taking duloxetine as of June 19, 2005.

  • The French journal Prescrire International published this opinion: "In practice, duloxetine currently has no place in the treatment of depression or diabetic neuropathy. Its efficacy has not yet been demonstrated to be even equivalent to that of other available drugs, and it has too many adverse effects, given this degree of uncertainty."

  • The Los Angeles County Department of Coroner released a report of the first post mortem studies of duloxetine; they identified twelve cases in which duloxetine was the ultimate cause of death. Five cases were declared multiple drug intoxication, and two were declared suicide.

  • A case of hyponatremia induced by duloxetine was reported by doctors at Weill Cornell Medical College in New York.

  • A case of dyskinesia during treatment with duloxetine was reported in Germany.

  • Two episodes of serotonin syndrome have been documented in the use of duloxetine in conjunction with other medications.

  • A case of fulminant hepatic failure involving duloxetine which resulted in death was reported by the Department of Internal Medicine, Ohio State University, Columbus, Ohio.

  • An acute attack of porphyria in a patient taking duloxetine.

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